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Tout au long de ce livre, l'argument majeur de Gassendi consiste en effet \u00e0 souligner la contradiction qu'il y a \u00e0 vouloir concilier, comme le fait Descartes, d'une part la distinction r\u00e9elle des substances pensante et \u00e9tendue (leur opposition d'essence), et d'autre part leur union de fait (dans la VIe M\u00e9ditation); une union qui demeure, de l'aveu m\u00eame de Descartes, inexplicable.Afin d'\u00e9chapper \u00e0 cette aporie du dualisme radical, et remarquant \u00e0 juste titre que Descartes postule, sans jamais prouver qu'il serait contradictoire pour une chose \u00e9tendue de penser, Gassendi est d\u00e8s lors conduit \u00e0 proposer une th\u00e9orie substitutive, celle d'un dualisme r\u00e9duit o\u00f9 l'opposition d'essence serait remplac\u00e9e par une diff\u00e9rence de degr\u00e9s: plut\u00f4t qu'\u00e0 deux substances irr\u00e9ductiblement oppos\u00e9es, il se pourrait que l'on ait affaire, note Gassendi, \u00e0 \u00ab une seule substance avec deux 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